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Hypercholesterolemia is a condition in which the concentration of cholesterol in the blood exceeds the normal value. Yogurt is food product that has been shown to lower blood. The addition of inulin can support the cholesterol-lowering effect of yogurt. Gembili (Dioscorea esculenta L.) is a high inulin food ingredient. This study aims to determine the effect of giving gembili yogurt (D. esculenta L.) on the lipid profile (total cholesterol, LDL, and triglyceride) of hypercholesterolemic rats. The study was conducted on 30 male hypercholesterolemic Wistar rats which were grouped using a simple randomized system into 1 control group and 4 intervention groups. Subjects were given 1, 2, 3, and 4 ml/day of gembili yogurt for 14 days. Total cholesterol, and LDL were determined using the CHOD-PAP method and triglyceride level was determined using the GPO-PAP method. Giving gembili yogurt with doses of 1, 2, 3, and 4 ml/day within 2 weeks could significantly reduce lipid profile on hypercholesterolemic rats, the largest decrease was occurred at group with a dose of 4 ml yoghurt/day with total cholesterol levels of 100.68 mg/dl, LDL levels 28.87, and triglyceride levels 85.80 mg/dl


Gembili yogurt Inuin Lipid profile Hypercholesterolemia

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How to Cite
Rahmasari, E. O., & Rosida. (2023). The Effect of Gembili Yogurt (Dioscorea esculenta L.) Intake on Lipid Profile of Hypercholesterolemic Rats. Food Science and Technology Journal (Foodscitech), 25-32.


  1. Anonim. (2019). Jakarta: Kemenkes RI
  2. Akoma, O., Elekwa, U.O., Afodunrinbi, A.T., Onyeukwu, G.C. (2000). Yogurt from Coconut and Tigernuts. J. Food Technol Afr. 5(4):132-4.
  3. Allegeyer, L.C., M. J. Miller and S. Y. Lee. (2010). Sensory and Microbiological Quality of Yogurt Drinks with Prebiotic and Probiotics. Journal of Dairy Science 93 (10): 4471-4479
  4. Allgeyer, L.C., M.J. Miller dan S.Y. Lee. (2010). Sensory and microbial quality of yogurt drinks with prebiotics and probiotics. J Dairy Sci. 93: 4471-4479. Dietary modulation of the human colonic microbiota: updating the concept of prebiotics.
  5. Anandharaj M, Sivasankari B, dan Rani RP. (2014). Effects of Probiotics, Prebiotics, and Synbiotics on Hypercholesterolemia: A Review. Chinese Journal of Biology Volume 2014, Article ID 572754, 7 pages.
  6. Baroutkoub, A., Mehdi, Z.R., Belglarian, Hassan, J., Zahra, S., Mohammad, S.M., et al. Effects of Probiotic Yoghurt Consumption on The Serum Cholesterol Levels in Hypercholesterolemic Cases in Shiraz Southern Iran. (2010). Scientic Research and Essays. 5(16):2026-9.
  7. Beylot, M. (2005). Effects of Inulin-Type Fructans On Lipid Metabolism In Man And In Animal Models. British Journal of Nutrition. 93, Suppl. 1, S163–S168.
  8. Central Bureau of Statistics, 2011. Table of Food Crops and Horticulture Central Java. (Badan Pusat Statistik. (2011). Tabel Tanaman Pangan dan Holtikultura Provinsi. Jawa Tengah.)
  9. Chiang, Y.R., Ismail, W., Heintz, D., Schaeffer, C., van Dorsselaer, A., Fuchs, G. (2010). Study of Anoxic and Oxic Cholesterol Metabolism by Sterolibacterium denitrificans. J. Bacteriol. 2008, 190, 905-914.
  10. Christine, M. W. (2009). Effect Inulin on Lipid Parameters in Humans. Volume 129, Issue 7 July, Pages 1471S-1473S
  11. Glenn R Gibson 1, Hollie M Probert, Jan Van Loo, Robert A Rastall, Marcel B Roberfroid Nutr Res Rev. (2004). Dec;17(2):259-75
  12. Glibowski, P., M. K. Wiater and A. Glibowska. (2011). Effect of Storage on Texture and Microbiological Stability of O-W Emulsions with Insulin. Czech Journal Food Science. Vol 29. No. 2: 137-144.
  13. Hai-Qing Ye, Ruishu Yang, Cuina Wang, Feng Gao, Jianjun Cheng, Tiehua Zhang, Mingruo Guo. (2016). Effects of Feeding Hyperlipidemic Rats with Symbiotic Oat-Based Frozen Yogurt on Serum Triglycerides and Cholesterol. Advances in Nutrition, Volume 7, Issue 1, January 2016, Page 30A
  14. Hendrati. (2014). Pembuatan Yoghurt Menggunakan Starter Lactobacillus Bulgaricus dan Streptococcus Thermophilus. Jurnal Biologi
  15. Istianah, N. (2010). Proses Produksi Inulin dari Beberapa Jenis Umbi Uwi (Dioscorea spp.). Skripsi. Surabaya : UPN Veteran Jawa Timur.
  16. Karlina, R. (2013). Potensi Yogurt Tanpa Lemak dengan Penambahan Tepung Pisang dan Tepung Gembili Sebagai Alternatif Menurunkan Kolesterol. Journal of Nutrition College. 3 (2) : 16-25.
  17. Kaur, A. V. and Jones, P. J. H. (2012). Combination diet and exercise interventions for the treatment of dyslipidemia: An effective preliminary strategy to lower cholesterol levels?,” J. Nutr., vol. 135, no. 8, pp. 1829–1835, 2012.
  18. Lay, G.O. and Min, T.L. (2010). Cholesterol-Lowering Effects of Probiotics and Prebiotics: A Review of in Vivo and in Vitro Findings. Int. J. Mol. Sci. 11, 2499-2522.
  19. Letexier D. Diraison F. And Beylot M. (2002). Addition Of Inulin to A Moderately High-Carbohyrate Diet reduces Hepatic Lipogenesis And Plasma TriacyGlycerol Concentration In Humans. (Am. J. Clin. Nutr.2002:77:559-564)
  20. Lunenburg, Fred C. (2010). The. Decision Making Process,. National Forum Of Educational. Administration And Supervision. Journal 27 (4): 1-12.
  21. Nasar, E.S., Ismail, M.G., El Damarawi, A.M., El Din, A.A. Effect of Inulin on Metabolic Changes Produced by Fructose Rich Diet. (2013). Life Sci J. 10(2):1807-14
  22. Onge MP, Edward RF, Jones PJH. (2000). Consumption of fermented and non fermented dairy products: effects on cholesterol concentrations and metabolism. Am J Clin Nutr 71:674–81.
  23. Rachman, S.D., Djajasoepena, S., Kamara, D.S., Idar, I., Sutrisna,R., Safari, A., Suprijana, O., Ishmayana, S. (2015). Kualitas Yoghurt yang Dibuat Dengan Kultur Dua (Lactobacillus bulgaricus dan Streptococcus thermophilus) dan Tiga Bakteri (Lactobacillus bulgaricus, Streptococcus thermophilus dan Lactobacillus acidophilus)”, Jurnal Chimica et Natura Acta. Vol. 3(2): 76-79.
  24. Regie F., Adriyan P. (2015). Pengaruh Pemberian Yoghurt Sinbiotik Tanpa Lemak Dengan Penambahan Tepung Gembili Terhadap Kadar Trigliserida Tikus Hiperkolesterolemia. Journal of Nutrition College, Volume 4, Nomor 1, Tahun 2015, Halaman 57 – 61.
  25. Rosida, S. S.Santi, F.R.Rohman. (2021). Study of Proportion of Milk with Lesser Yam Filtrate and Starter Concentration for Producing Synbiotic Yoghurt. International Journal of Eco-Innovation in Science and Engineering Vol 2 (02) 2021 (20-25).
  26. Screzenmeir, J. and de Verse, M. 2001. Probiotics, prebiotics and synbiotics Approaching a definition. Am. J. Clin. Nutr. 73(2):361S–364S.
  27. Senanayake SA, Ranaweera KKDS, Bamunuarachchi A, Gunaratne A. 2013. Proximate analysis and phyto-chemical and mineral constituents in four cultivars of yams and tuber crops In Sri Lanka. Trop Agric Res Ext 15(1):32–36.
  28. Surya, S., Ani, M. (2015). Pengaruh Pemberian Yoghurt Sinbiotik Tanpa Lemak Dengan Penambahan Tepung Gembili (Dioscorea Esculenta) Terhadap Kadar Kolesterol Total Tikus Hiperkolesterolemia. Journal of Nutrition College, Volume 4, Nomor 2, Halaman 104-109.
  29. Tomas, L. G., S. Bayarri and E. Costell. (2009). Inulin-enriched Dairy Desserts : Physicochemical and Sensory Aspects. Journal DairyScience. Vol. 92:4188-4199.
  30. Yudhasari, J. D. (2008). Pengaruh Pemberian Susu Fermentasi terhadap Kadar Kolesterol dalam Darah Mencit (Mus musculus Gazaensis) Galur Swiss Webster. Skripsi. Fakultas Teknobiologi. Yogyakarta : UAJY.
  31. Zainudin, A., Wasito, B.E., Puspaningsih, T.N.N. Pengujian in Vivo Xilooligosakarida sebagai Kandidat Prebiotik. (2009) ;14:101-11
  32. Zhang and Zhang. (2013). Intenstinal Structure and Function of Broiler Chicken on Diets Supplementd with A Synbiotic Containing Enteroccus faecium and Oligosaccarides. Int J Mol, Sci. 9.